Figure 2.

One-year cumulative incidence of TB infection (TBI) and TB disease (TBD) in household contacts of rifampin- or multidrug-resistant TB index cases. One-year cumulative incidence of TBI defined by IGRA conversion with comparisons made between age groups (A) and HIV status (B). One-year cumulative incidence of TBD stratified by confirmed/probable TB and possible disease with comparisons made between age groups (C) and risk group (D). High-risk group includes age <5 (regardless of HIV and TBI status); age ≥5 years diagnosed with HIV (regardless of TBI status); and age ≥5, and not diagnosed with HIV, baseline TST/IGRA positive. Cumulative incidence estimated using generalized estimated equations to account for household clustering. Longitudinal bars represent 95% confidence intervals. Abbreviations: HIV, human immunodeficiency virus; IGRA, interferon-gamma release assay; TB, tuberculosis; TST, tuberculin skin test.