Skip to main content
. 2023 Jul 1;119(10):1905–1914. doi: 10.1093/cvr/cvad100

Figure 1.

Figure 1

Uptake of circulating lipids. The heart obtains fatty acids (FAs) from circulating triglyceride-rich lipoproteins (chylomicrons and VLDL) and albumin-bound non-esterified FAs. Lipoprotein lipase (LpL) catalyses hydrolysis of triglyceride-rich lipoproteins at the endothelial cell surface. FA uptake by the heart requires transport across the endothelial cell barrier, which is mediated by the scavenger receptor CD36. Genetic deletion of CD36 or LpL or overexpression of the LpL inhibitor angiopoietin-like protein 4 (Angptl4) leads to defective lipid uptake and heart dysfunction.