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Study design of the two-sample MR for the effect of the genetically predicted gut microbiome and gut metabolites on digestive tract cancer. MiBioGen: international consortium MiBioGen; TwinsUK Registry: the UK adult twin registry; FHS: Framingham Heart Study; LD: linkage disequilibrium; SNP: single-nucleotide polymorphism; MR: Mendelian randomization; IVs: instrumental variables; IVW: inverse-variance weighted.
