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. 2023 Oct 31;21:5531–5537. doi: 10.1016/j.csbj.2023.10.053

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© 2023 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 3 — CDH2 expression correlates with EMT markers in breast cancer patients. (A) A screenshot of the summary table. Size: number of genes in the gene set. NES: Normalized enrichment score. NOM p-value: nominal p-value. FWER p-value: Family-wise error rate. FDRq-value: False discovery rate. (B) A screenshot of a summary dot plot of upregulated and downregulated gene sets of CDH2 correlated genes. The results are colored based on the FDR values, and the ball size is set by the number of genes in the gene set. The gene sets are sorted ascendingly according to their FWER p-values. (C) A screenshot of the network plot of CDH2 correlated gene sets. The results are colored by FDR, and the ball size is set by the gene set size. (D) GSEA plot of the Hallmark of Epithelial-Mesenchymal Transition (EMT) shows a positive and significant correlation of CDH2 with the EMT markers in breast cancer patients. (E) Screenshot of the detailed result of the hallmark of the EMT. (F) A screenshot of the EMT gene list and Spearman's rank correlation coefficient with CDH2 expression. (G) GSEA plot of Hallmark of Oxidative Phosphorylation (OXPHOS) shows a negative correlation with CDH2 expression in breast cancer patients.