Table 1.
Demographic, clinical and outcome features of 1169 high hyperdiploid cases stratified by UKALL HeH Risk Group.
| Total | Good risk | Poor risk | ||
|---|---|---|---|---|
| 1169 (100) | 865(100) | 304(100) | p-value | |
| Sex | 0.31 | |||
| Female | 550 (47) | 415 (48) | 135 (44) | |
| Male | 619 (53) | 450 (52) | 169 (56) | |
| Age | <0.001 | |||
| 1–9 | 914 (78) | 706 (82) | 208 (68) | |
| 10–14 | 108 (9) | 69 (8) | 39 (13) | |
| 15–24 | 106 (9) | 75 (9) | 31 (10) | |
| 25+ | 41 (4) | 15 (2) | 26 (9) | |
| White cell count (×109/L) | 0.016 | |||
| 0–49 | 1026 (91) | 769 (91) | 257 (89) | |
| 50–99 | 72 (6) | 56 (7) | 16 (6) | |
| 100+ | 32 (3) | 17 (2) | 15 (5) | |
| End of induction Minimal Residual Disease (MRD) value | 0.85 | |||
| <0.01% | 647 (70) | 495 (69) | 152 (70) | |
| ≥0.01% | 282 (30) | 218 (31) | 64 (30) | |
| HeH specific threshold | ||||
| <0.03% | 751 (81) | 576 (81) | 175 (81) | |
| ≥0.03% | 178 (19) | 137 (19) | 41 (19) | |
| Relapse rate | ||||
| Number of relapses (%) | 96 (9) | 46 (6) | 50 (18) | <0.001 |
| Relapse rate at 5 years | 9% (7–11) | 6% (4–7) | 19% (14–23) | |
| Unadjusted Hazard Ratio (CI), p-value | 3.52 (2.36–5.25), p < 0.001 | |||
| Adjusteda Hazard Ratio (CI), p-value | 3.30 (1.97–5.52), p < 0.001 | |||
| Event-free survival | ||||
| Number of events (%) | 145 (12) | 76 (9) | 69 (23) | <0.001 |
| Event Free Survival at 5 years | 87% (85–89) | 91% (89–93) | 77% (72–82) | |
| Unadjusted Hazard Ratio (CI), p-value | 2.80 (2.02–3.87), p < 0.001 | |||
| Adjusteda Hazard Ratio (CI), p-value | 2.84 (1.80–4.45), p < 0.001 | |||
| Overall survival | ||||
| Number of deaths (%) | 103 (9) | 50 (6) | 53 (17) | <0.001 |
| Event Free Survival at 5 years | 92% (90–94) | 95% (93–96) | 84% (80–88) | |
| Unadjusted Hazard Ratio (CI), p-value | 3.21 (2.18–4.73), p < 0.001 | |||
| Adjusteda Hazard Ratio (CI), p-value | 3.72 (1.98–6.97), p < 0.001 | |||
Minimal residual disease (continuous).
CI confidence interval.
aadjusted for Minimal residual disease (MRD).