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. 2023 Nov 2;24(12):2068–2079. doi: 10.1038/s41590-023-01661-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — (a) Confocal microscopy images show the intracellular accumulation of SARS-CoV-2 dsRNA in BALF CD64⁺ Mac from WTM and OM at ≥221 days p.i., cultured with or without IFN-γ. DAPI (nucleus) is in purple, and anti-dsRNA staining (SARS-CoV-2 dsRNA) is in red. (b) Measurement of SARS-CoV-2 dsRNA MFI in CD64⁺ Macs isolated from BALF of WTM, and OM at ≥221 days p.i., cultured with or without IFN-γ. (c) Confocal microscopy images depict MHC-E localization in BALF CD64⁺ Macs from WTM and OM at ≥221 days p.i., cultured with or without IFN-γ stimulation. DAPI (nucleus) is in blue, anti-dsRNA staining (SARS-CoV-2 dsRNA) is in red, and anti-MHC-E staining is in green. (d) Measurement of MHC-E MFI in CD64⁺ Macs isolated from BALF of WTM, and OM at ≥221 days p.i., cultured with or without IFN-γ. In each graph, median and interquartile range are shown. p-Values were determined using a 2-way ANOVA test with Šídák’s multiple comparisons test correction.

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