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. 2023 Nov 2;24(12):2068–2079. doi: 10.1038/s41590-023-01661-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a, Representative GzmB and IFN-γ expression plots in NKG2R^lo and NKG2R^hi NK cells from WTM (n = 15) and OM (n = 10), isolated ≥221 d p.i., cultured with or without spike protein. b,c, GzmB and IFN-γ expression in NKG2R^hi and NKG2R^lo NK cells from WTM (b) and OM (c), isolated ≥221 d p.i., cultured with DMSO, LPS, trimeric spike, spike domain S1 or spike domain S2. d, GzmB and IFN-γ expression in NKG2R^hi and NKG2R^lo NK cells from WTM^neg, WTM^lo, WTM^hi, OM^neg, OM^lo and OM^hi, isolated ≥221 d p.i., and cultured with spike protein for 24 h. Each symbol represents an individual; bars represent medians. Interquartile ranges are shown. In all graphs, P values were determined by Kruskal–Wallis test with Dunn’s post hoc test.

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