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. 2023 Nov 7;37(12):2367–2382. doi: 10.1038/s41375-023-02041-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A PDP1 protein levels in 32D cells under FLT3-ITD kinase activity, IL3 signaling or their combination (n = 2). B qPCR measurements of PDP1 mRNA levels in 32D cells under FLT3-ITD vs IL3 signaling (n = 4). C Western blot of S293 inhibitory phosphorylation levels of PDHA1 (n = 3). D PDP1 protein levels in FLT3-ITD-positive AML cell lines compared to their FLT3-WT counterparts (n = 2). E PDP1 mRNA expression levels in primary AML blasts (FLT3-WT vs FLT3-ITD, n = 108 and 33, respectively) extracted from the TCGA AML cohort (https://tcga-data.nci.nih.gov/tcga). F PDP1 protein levels in AML blasts (FLT3-WT vs FLT3-ITD) (n = 37 and 128, respectively) extracted from the AML proteogenomic cohort [52] (https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00058-7). G PDP1 protein levels in primary AML CD34⁺ cells and healthy CD34⁺ HSPCs (Healthy HSPCs vs FLT3-WT vs FLT3-ITD, n = 6, 17 and 27, respectively) extracted from Boer et al. 2018 [53] (https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30374-X). Data are presented as mean values ± SD. In (D), (E) and (F), unpaired Student’s t-test was performed (**P ≤ 0.01, *P ≤ 0.05). In (A) and (G), one-way ANOVA with Bonferroni’s multiple comparisons was performed (**P ≤ 0.01, *P ≤ 0.05).