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. 2023 Nov 7;37(12):2367–2382. doi: 10.1038/s41375-023-02041-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Cumulative growth assays upon PDP1 knockdown under hypoxic conditions in FLT3-WT compared to FLT3-ITD cell lines. B Seahorse OCR measurements of respiration capacity in FLT3-WT AML cell lines and primary patient-derived AML blasts after adaption to hypoxic conditions (n = 2). C Respiration capacity of FLT3-ITD cells after adaption to hypoxia (representative experiment with two biological replicates). D Respiration capacity of Molm13 cells adapted to hypoxia (7 days) with prior PDP1 knockdown (3 days before the experiment). Statistical analysis for this experiment is shown for five technical replicates. Data are presented as mean values ± SD. In (B), two-way ANOVA with Bonferroni’s two group comparisons was performed (****p ≤ 0.0001, *p ≤ 0.05).