Table 2.

Loci identified by the meta-analysis of COVID-19 vaccine adverse events.

reaction	variant	CHR	Position	EA	NEA	EAF	dose	BNT162b1 vaccine			mRNA-1273 vaccine
								OR	SE	P	OR	SE	P
Itching at vaccination site	rs10744866	12	110104688	A	T	0.37	1st	0.89	0.12	0.317	0.55	0.11	2.42 × 10−8
							2nd	1.10	0.11	0.404	0.88	0.11	0.239
Movement disorder at vaccination site	rs146922515	10	23658821	CA	C	0.43	1st	1.13	0.07	0.0783	1.23	0.09	0.0286
							2nd	1.03	0.08	0.738	1.80	0.11	3.69 × 10−8
Internal bleeding at vaccination site	rs1217097	8	64623330	A	G	0.24	1st	4.12	0.24	1.79 × 10−9	1.11	0.41	0.797
							2nd	1.85	0.34	0.0699	0.25	0.78	0.0768
37.5 °C or higher fever	rs551634406	6	30965800	(A)15TAT	A	0.49	1st	0.90	0.11	0.354	0.96	0.11	0.703
							2nd	0.66	0.07	1.09 × 10−9	0.84	0.12	0.127
37.5 °C or higher fever	rs183300	6	33526951	C	T	0.46	1st	0.97	0.11	0.741	0.91	0.10	0.359
							2nd	0.66	0.06	3.39 × 10−11	0.82	0.11	0.0736
38 °C or higher fever	rs9266082	6	31320022	C	T	0.39	1st	1.31	0.21	0.201	1.39	0.16	0.0448
							2nd	1.60	0.08	4.59 × 10−9	1.13	0.09	0.144
38 °C or higher fever	rs375726766	6	33335716	C	CA	0.36	1st	1.04	0.23	0.856	0.90	0.18	0.556
							2nd	0.60	0.09	3.67 × 10−8	0.98	0.09	0.855
Peripheral coolness	rs10205263	2	221076324	C	T	0.090	1st	13.09	0.44	7.30 × 10−9	1.31	0.93	0.771
							2nd	3.61	0.41	0.00180	0.37	0.56	0.0777
Dizzy	rs67053119	8	51750913	T	A	0.075	1st	0.52	0.63	0.300	1.25	0.63	0.726
							2nd	0.93	0.38	0.851	5.84	0.32	2.94 × 10−8
Chest pain	rs13279405	8	12986585	T	C	0.056	1st	17.29	0.51	2.69 × 10−8	7.87	0.68	0.00225
							2nd	5.66	0.56	0.00210	4.38	1.02	0.146
Abdominal discomfort	rs57177321	11	33988111	T	C	0.10	1st	7.63	0.36	2.30 × 10−8	0.71	0.91	0.705
							2nd	1.94	0.50	0.182	0.43	0.82	0.301
Joint pain	rs34086990	8	81791475	A	AT	0.19	1st	0.72	0.31	0.284	3.78	0.24	3.94 × 10−8
							2nd	1.07	0.18	0.708	1.34	0.18	0.0962
Muscle pain	rs3135408	6	33275013	C	T	0.36	1st	0.82	0.09	0.0392	0.84	0.11	0.111
							2nd	0.56	0.10	1.13 × 10−8	0.88	0.10	0.222
Urticaria	rs2274569	1	100435079	C	T	0.064	1st	3.82	0.51	0.00811	2.94	0.79	0.170
							2nd	11.78	0.45	3.15 × 10−8	1.91	1.23	0.600

Loci that reached genome-wide significance after the meta-analysis following the 1st or 2nd dose of the BNT162b1 or mRNA-1273 vaccines. CHR, chromosome; EA, effect allele; NEA, non-effect allele; EAF, effect allele frequency in the entire our study subjects; OR, odds ratio of effect allele; SE, standard error for beta of effect allele; P, p-value.

Significant values are in bold.