Table 3.
Allele frequency and expression quantitative trait locus (eQTL) genes of the loci associated with the COVID-19 vaccine adverse events.
| Variant | Associated reaction | Location | Allele frequency | eQTL genes | |
|---|---|---|---|---|---|
| European | Japanese | ||||
| rs10744866 | Itching at vaccination site | 12q24 | 0.20 | 0.37 | MVK, FOXN4, KCTD10 |
| rs146922515 | Movement disorder at vaccination site | 10p12 | 0.35 | 0.43 | None in GTEx |
| rs1217097 | Internal bleeding at vaccination site | 8q12 | 0.28 | 0.24 | RP11-579E24.2, LINC01289 |
| rs551634406 | 37.5 °C or higher fever | 6p21 | 1.00 | 0.49 | None in GTEx |
| rs183300 | 37.5 °C or higher fever | 6p21 | 0.65 | 0.46 | BAK1, COL11A2, DAXX, IP6K3 |
| rs9266082 | 38 °C or higher fever | 6p21 | 0.30 | 0.39 | C4B, CCHCR1, CSNK2B, HCG22, HCG27, HLA-B, HLA-C, HSPA1B, MICB, MIR6891, NOTCH4, POU5F1, PSORS1C1, PSORS1C2, RNF5, SFTA2, TCF19, USP8P1, VARS2, VWA7, WASF5P, XXbac-BPG181B23.7, XXbac-BPG248L24.12, XXbac-BPG299F13.17 |
| rs375726766 | 38 °C or higher fever | 6p21 | 0.60 | 0.36 | None in GTEx |
| rs10205263 | Peripheral coolness | 2q35 | 0.071 | 0.09 | No eQTL genes |
| rs67053119 | Dizzy | 8q11 | 0.12 | 0.075 | No eQTL genes |
| rs13279405 | Chest pain | 8p22 | 0.24 | 0.056 | No eQTL genes |
| rs57177321 | Abdominal discomfort | 11p13 | 0.072 | 0.1 | No eQTL genes |
| rs34086990 | Joint pain | 8q21 | 0.042 | 0.19 | None in GTEx |
| rs3135408 | Muscle pain | 6p21 | 0.54 | 0.36 | B3GALT4, BAK1, DAXX, HCG24, HCG25, HLA-DPA1, RGL2, RPS18, TAPBP, WDR46, ZBTB22 |
| rs2274569 | Urticaria | 1p21 | 0.076 | 0.064 | DBT, LRRC39, MFSD14A, RTCA, SASS6, SLC35A3, TRMT13 |
European allele frequency, the allele frequency of European individuals (non-Finnish) in gnomAD v2,1,1; Japanese allele frequency, allele frequency in this study; eQTL genes, Variants associated with the COVID-19 vaccine adverse events were associated with the gene expression in GTEx (p-value < 0.0005).