Figure 2.

DNASE1L3 affects wound healing by inducing intensive collagen deposition

(A and E) DNases appear not to affect SMA in short- and long-term which is a marker of wound contractility.

(B, C, F, G, and I) Collagen 1:3 ratio and collagen alignment are used to access wound maturation. In Dnase1l3 knockout mice very high levels of collagen I and III were to be found. Even after three weeks, the collagen fibrils remained aligned in parallel. This pattern is often associated with an immature wound and fibrosis.

(D and H) Fibrin remained the same in all groups. Data shown as mean ± SD. Statistics: Kruskal-Wallis test with Dunn’s correction.