REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Goat anti-mouse MPO (Figures 5, S3, S6, S8)	R&D Systems	RRID:AB_2250866
Rabbit anti-mouse NE (Figures 5, S3, S6)	Abcam	RRID:AB_1658868
Rabbit anti-mouse citH3 (Figures S3; S6; S8)	Abcam	CAT # ab219406
Rabbit anti-human DNase1L3 (Figures 5, S3, S6)	ThermoFisher	CAT# BS7653R
Mouse anti-DNA (Figure S8)	Merck	RRID:AB_93367
Rabbit anti-human fibrinogen (Figure S8)	Abcam	RRID:AB_10561758
Rabbit anti-human CCR2 (Figures 5, S6)	ThermoFisher	RRID:AB_11154101
Mouse anti-human CD68 (Figures 5, S6)	Abcam	RRID:AB_307338
Normal Goat IgG Control (Figures 5, S6)	R&D Systems	RRID:AB_354267
Rabbit IgG, polyclonal - Isotype Control (Figures 5, S6)	Abcam	RRID:AB_2631996
Rabbit IgG, monoclonal [EPR25A] Antibody (Figures 5, S6)	Abcam	RRID:AB_2687931
Biological samples
Peritoneal tissue samples	Pediatric Surgery of the University Medical Center Hamburg-Eppendorf, Department of Surgery of the University Hospital Erlangen	N/A
Chemicals, peptides, and recombinant proteins
Dornase alfa (Figure 4)	Roche	CAT# 0471672800
NTR-10 (Figure 3)	Neutrolis	N/A
Isoflurane	Baxter	N/A
Buprenorphine	Reckitt Benckiser	N/A
Target Retrieval Solution pH6	Agilent	CAT # S2369
Donkey Block	BioGenex	N/A
Fluoromount-G	Southern Biotech	CAT # 0100-01
Fluorogenic substrate MeOSuc-AAPV-AMC	Santa Cruz Biotechnology	CAT # sc-201163
SYTOX™ Orange Nucleic Acid Stain (Figure S1)	ThermoFisher	CAT # S11368
Neutrophil elastase from human leukocytes (Figure S4)	Sigma-Aldrich	CAT # E8140
Sivelestat sodium salt hydrate (Figure S4)	Sigma-Aldrich	CAT# S7198
Alpha-1-Antitrypsin (Figure S4)	Sigma-Aldrich	CAT# A9024
Critical commercial assays
Picro Sirius Red Stain Kit (Figure 2)	Abcam	CAT# ab150681
Deposited data
RNA data	Harvard Dataverse	https://doi.org/10.7910/DVN/V9NWVB
Experimental models: Cell lines
JM8A3 embryonic stem cells (C57BL/6N origin)	University Medical Center Mannheim	RRID:CVCL_J959
Experimental models: Organisms/strains
C57BL/6J Mus musculus	Jackson Laboratories	IMSR_JAX:000664
C57BL/6N Mus musculus	University Medical Center Mannheim	N/A
DNase1-KO Mus musculus	University Medical Center Mannheim	N/A
Dnase1l3-KO Mus musculus	University Medical Center Mannheim	N/A
B6.Cg-Padi4tm1.1Kmow/J Mus musculus	Jackson Laboratories	RRID:IMSR_JAX:030315
Recombinant DNA
pX458	Addgene	RRID:Addgene_159654