Table 5.
Change from baseline in EoE-IQ average score at week 24 using PGIS and PGIC anchor measures
| Anchor measure/anchor group | EoE-IQ average change score from baseline to week 24 | |||
|---|---|---|---|---|
| n | Mean (SD) | 95% CI | Median | |
| PGIS | ||||
| Worsening (≥ 1-point worsening) | 12 | 0.062 (0.7182) | − 0.3943 to 0.5183 | − 0.091 |
| 0-point change | 65 | − 0.394 (0.4854) | − 0.5146 to − 0.2740 | − 0.364 |
| 1-point improvement | 93 | − 0.713 (0.5527) | − 0.8268 to − 0.5992 | − 0.636 |
| 2-point improvement | 25 | − 1.277 (0.5060) | − 1.4857 to − 1.0680 | − 1.222 |
| 3-point improvement | 3 | − 2.054 (0.6833) | − 3.7513 to − 0.3564 | − 1.909 |
| PGIC | ||||
| Worsening (A little worse, Moderately worse, Very much worse) | 9 | 0.251 (0.7648) | − 0.3365 to 0.8393 | 0.182 |
| No change | 29 | − 0.231 (0.3785) | − 0.3747 to − 0.0868 | − 0.091 |
| A little better | 44 | − 0.610 (0.5780) | − 0.7852 to − 0.4338 | − 0.545 |
| Moderately better | 53 | − 0.842 (0.6140) | − 1.0112 to − 0.6727 | − 0.700 |
| Very much better | 63 | − 0.848 (0.6067) | − 1.0005 to − 0.6949 | − 0.818 |
CI, confidence interval; EoE-IQ, Eosinophilic Esophagitis Impact Questionnaire; PGIC, Patient Global Impression of Change; PGIS, Patient Global Impression of Severity; SD, standard deviation