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. 2023 Nov 27;14:7780. doi: 10.1038/s41467-023-43387-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Genotyping PCR on genomic DNA isolated from matched patient samples using gene-specific primers for IGF2BP2::TESPA1 genomic breakpoint (top), wt TESPA1 (middle) and wt IGF2BP2 (bottom). n = 2 patients, 4 samples per patient, depending on biological material available. Source images are provided as a Source Data file. b Copy number values per subclone in Patient 2 scDNA-seq data. Sublone 0 has multiple copy number alterations, indicative of cancer, while Subclone 1 is copy number neutral, presumably non-cancer. c IGV view of scDNA reads aligning unambiguously to the IGF2BP2::TESPA1 genomic breakpoint (top), wt TESPA1 (middle), or wt IGF2BP2 (bottom). In red, reads from Subclone 0 cells (cancer); in blue, reads from Subclone 1 cells (non-cancer).