Fig. 1. Study design, response outcomes, survival analysis, and mutational landscape of the unmatched VEN+HMA cohort.
a Flow chart of inclusion of patients for propensity score matching analysis. b Treatment response of matched patients to the first course of induction treatment with VEN + HMA or standard 7 + 3. c Relapse-free survival in the matched cohorts. d Overall survival in the matched cohorts. e Mutational landscape of the unmatched 21 patients treated with VEN + HMA. Oncoprint shows mutational characteristics at diagnosis. Patients are grouped by best response after 1–2 induction cycles and are labeled with colored bars on the right. The filled bars on the right show the percentage of patients achieving CRc in the presence of each gene mutation. The asterisk indicates genes with a P < 0.05 percentage of CRc.