Table II:

Top biological functions of RNAseq dataset from the brain of LD mice in comparison to wild type ordered by z-score (z-score >2 was defined as the threshold of significant activation). The p-value and the genes involved in the corresponding biological functions are indicated.

Diseases and Biological functions	z-score	p-value	Genes from the data set
Cell movement of granulocytes	3.51	1.33 E-16	C3, CCL2, CCL5, CD74, CHIL4, CXCL6, CXCL10, IL1RL1, LCN2, MMP12, TIMP1
Homeostasis of leukocytes	3.42	4.42 E-16	ARG1, C3, CCL2, CCL5, CD74, CXCL6, CXCL10, IL1RL1, LCN2
Cellular infiltration	3.27	1.24 E-16	ARG1, C3, CCL2, CCL5, CHIL4, CXCL10, IL1RL1, LCN2, MMP12, TIMP1
Inflammatory response	2.89	1.25 E-14	C3, CCL2, CCL5, CD74, CHIL4, CLEC7A, CXCL6, CXCL10, FCGR3A, HCAR2, IL1RL1, LCN2, LYZ, RENTLA
Phagocytosis	2.81	5.37 E-11	C3, CCL2, CCL5, CLEC7A, CXCL10, FCGR3A, IL1RL1, LCN2
Immune response of cells	2.78	1.05 E-19	ARG1, C3, CCL2, CCL5, CD74, CLEC7A, CXCL10, FCGR3A, IL1RL1, ITGAX, LCN2