Table 2.
Results derived from GAMLSS when testing for associations between sleep parameters and MTsat values computed over brainstem monoaminergic grey matter (bmGM) with age as interacting variable. Significant values are in bold.
| Sleep parameters | SOL | SWE | SE | REMS % | REMS theta Power | REMS Arousal (N) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Estimate | p-value (95% CI) | Estimate | p-value (95% CI) | Estimate | p-value (95% CI) | Estimate | p-value (95% CI) | Estimate | p-value (95% CI) | Estimate | p-value (95% CI) | |
| MTsat value bmGM | − 48.60 | 2.2e−05 (− 62.1, − 35.1) | 41.40 | 0.01 (9.1, 73.7) | 0.63 | 0.14 (0.34, 0.86) | − 0.40 | 0.89 (− 6.46, 5.67) | 12.1 | 0.28 (− 9.71, 33.8) | 4.23 | 0.57 (− 10.60, 19.0) |
| Age | − 0.49 | 1.2e−04 (− 0.65, − 0.34) | 0.38 | 0.04 (0.01, 0.74) | 0.01 | 0.17 (0.004, 0.01) | − 0.01 | 0.88 (− 0.07, 0.06) | 0.08 | 0.51 (− 0.17, 0.33) | 0.07 | 0.41 (− 0.10, 0.24) |
| Age*MTsat bmGM | 2.11 | 5.1e−05 (1.5, 2.73) | − 1.84 | 0.01 (− 3.32, − 0.37) | − 0.03 | 0.12 (− 0.04, − 1.83) | 0.02 | 0.88 (− 0.26, 0.3) | − 0.53 | 0.30 (− 1.53, 0.47) | − 0.15 | 0.65 (− 0.83, 0.52) |
| BMI | − 0.058 | 2.52e−04 (− 0.09, − 0.027) | − 0.034 | 0.12 (− 0.008, 0.08) | 0.001 | 0.33 (− 0.001, 0.002) | 0.01 | 0.02 (0.002, 0.02) | 0.03 | 0.03 (0.004, 0.06) | 0.006 | 0.57 (− 0.03, 0.01) |
| TST | 0.002 | 0.03 (0.0002, 0.004) | − 0.001 | 0.26 (− 0.004, 0.001) | − 4.7e−05 | 0.14 (− 0.0001, 2.1e−05) | 0.001 | 0.01 (0.0001, 0.001) | 0.001 | 0.23 (− 0.0005, 0.003) | 0.004 | 2.5e−09 (0.003, 0.005) |
| TIV | 0.001 | 0.11 (− 0.0001, 0.001) | − 0.0002 | 0.66 (− 0.0003, − 0.0002) | 8.9e−07 | 0.94 (–, –) | − 4.4e−05 | 0.60 (− 0.0002, 0.0001) | − 1.2e−05 | 0.97 (− 3.9e−5, 1.6e−05) | − 2.1e−05 | 0.92 (− 4.4e−05, − 2.1e−06) |
| MPM sequence | 0.18 | 0.03 (0.02, 0.34) | − 0.14 | 0.23 (− 0.36, 0.09) | − 0.003 | 0.33 (− 0.01, 0.003) | 0.01 | 0.72 (− 0.03, 0.05) | 0.01 | 0.94 (− 0.15, 0.17) | 0.02 | 0.71 (− 0.09, 0.13) |
| Scanner type | − 0.13 | 0.31 (− 0.37, 0.11) | 0.03 | 0.87 (− 0.34, 0.39) | − 0.0002 | 0.96 (− 0.01, 0.01) | 0.004 | 0.90 (− 0.06, 0.07) | 0.11 | 0.39 (− 0.15, 0.36) | − 0.01 | 0.91 (− 0.17, 0.16) |
BMI body mass index, bmGM brainstem monoaminergic gray matter compartment, MPM sequence type of multiparameter sequence, 2 sequence types were used (N = 222 for type 1; N = 99 for type 2—see “Methods”), MRI scanner data were acquired on 2 separate scanners (N = 286 for scanner 1; N = 35 for scanner 2—see “Methods”), MTsat magnetisation transfer saturation, REMS rapid eye movement sleep, SE sleep efficiency, SOL sleep onset latency, SWE slow wave energy, TIV total intracranial volume, TST total sleep time.