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. Author manuscript; available in PMC: 2023 Nov 28.
Published in final edited form as: Aliment Pharmacol Ther. 2023 Feb 23;57(9):1014–1027. doi: 10.1111/apt.17424

TABLE 4.

Causes of death of all deceased patients in each BMI group.

Causes of death Total (n = 616) Lean (n = 111) Non-lean (n = 505) p value (lean vs. non-lean)
Overweight (n = 162) Obesity 1 (n = 136) Obesity 2–3 (n = 207)
Overall death 616/13,420 (4.6%) 111/1454 (7.6%) 162/3373 (4.8%) 136/3830 (3.6%) 207/4763 (4.3%) <0.0001
Cardiovascular diseases 190 (30.8%) 29 (26.1%) 46 (28.4%) 45 (33.1%) 70 (33.8%) 0.24
Neoplasms 103 (16.7%) 14 (12.6%) 31 (19.1%) 21 (15.4%) 37 (17.9%) 0.20
 Digestive and liver cancers 33 (5.4%) 3 (2.7%) 7 (4.3%) 12 (8.8%) 11 (5.3%) 0.17
 Other neoplasmsa 70 (11.3%) 11 (9.9%) 24 (14.8%) 9 (6.6%) 26 (12.6%) 0.59
Respiratory diseases 75 (12.2%) 17 (15.3%) 15 (9.3%) 18 (13.2%) 25 (12.1%) 0.26
Digestive diseases 48 (7.8%) 11 (9.9%) 13 (8.0%) 8 (5.9%) 16 (7.7%) 0.36
 Liver diseases 33 (5.4%) 8 (7.2%) 8 (4.9%) 6 (4.4%) 11 (5.3%) 0.34
 Digestive diseases other than liver diseases 15 (2.4%) 3 (2.7%) 5 (3.1%) 2 (1.5%) 5 (2.4%) 0.84
External causeb 45 (7.3%) 6 (5.4%) 19 (11.7%) 12 (8.8%) 8 (3.9%) 0.40
Mental-neurological diseases 40 (6.5%) 9 (8.1%) 13 (8.0%) 8 (5.9%) 10 (4.8%) 0.45
Metabolic diseasesc 36 (5.8%) 9 (8.1%) 6 (3.7%) 6 (4.4%) 15 (7.3%) 0.26
 Diabetes mellitus 7 (1.1%) 0 (0.0%) 2 (1.2%) 1 (0.7%) 4 (1.9%) 0.22
Infectious diseases 27 (4.4%) 6 (5.4%) 8 (4.9%) 3 (2.2%) 10 (4.8%) 0.56
Genitourinary diseases 25 (4.1%) 1 (0.9%) 4 (2.5%) 9 (6.62%) 11 (5.3%) 0.06
Musculoskeletal and connective tissue diseases 9 (1.5%) 3 (2.7%) 2 (1.2%) 3 (2.2%) 1 (1.5%) 0.23
Otherd 18 (2.9%) 6 (5.4%) 5 (3.1%) 3 (2.2%) 4 (1.9%) 0.09

Note: The cause of death was categorised based on the ICD-10-CM codes.

a

Other neoplasms refer to neoplasms that are other than digestive cancers, mainly including (1) C15-C26 Malignant neoplasms of digestive organs; (2) C30-C39 Malignant neoplasms of respiratory and intrathoracic organs; (3) C50-C50 Malignant neoplasms of breast; (4) C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system; (5) C81-C96 Malignant neoplasms of lymphoid, haematopoietic and related tissue; (6) D10-D36 Benign neoplasms, except benign neuroendocrine tumours and (7) D37-D48 Neoplasms of uncertain behaviour, polycythaemia vera and myelodysplastic syndromes.

b

External cause comprises (1) S00-T88 Injury, poisoning and certain other consequences of external causes and (2) V00-Y99 External causes of morbidity.

c

Metabolic diseases refer to E00-E89 Endocrine, nutritional and metabolic diseases.

d

Other includes (1) D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism; (2) Q00-Q99 Congenital malformations, deformations and chromosomal abnormalities and (3) R263 unknown.