Table 1.

Breast and NSCLC cancer cell lines, gene mutations, and sensitivity to MEN1611.

Cell line	PI3KCA	EGFR	MEN1611 IC50 (µM)
T-47D	H1047R	wt	0.08 ± 0.02
H1975 †	G118D	L858R; T790M	0.41 ± 0.14
MCF7	E545K	wt	1.37 ± 0.55
HCC4006 †	wt	ΔL747-E749; A750P	1.51 ± 0.27
HCC827 †	wt	ΔE746-A750	1.74 ± 0.35
H460 †	E545K	wt	1.92 ± 0.63
MDA-MB-231	wt	wt	2.15 ± 0.33

EGFR and PI3KCA mutations are shown. †: lung cancer cell lines. MEN1611 IC₅₀ (μM) mean values +/- SEM are representative of three independent experiments. In each experiment R square was > 0.9. Wild type:wt.