(B) % cleaved Casp3/nuclei
Drug	HCC827	RA1	RB1	RA2
Vehicle	5.8 ± 1.4	8.3 ± 1.2	9.8 ± 2.1	10.9 ± 2.6
MEN1611	8.4 ± 1.5*	12.2 ± 2.3**	11.4 ± 1.2	13.7 ± 1.3*

(A) Counts of Ki67+ cells in xenograft nodules. Images were captured from 4–6 slides and 2–4 nodules; at least 24 fields and 3,000 nuclei for each experimental condition were analyzed. Statistical analysis was achieved by ANOVA with Dunnett’s multiple comparison test (HCC827, RB1) or t-test (RA1, RA2). Geftinib, Gef; n.d., not determined. (B) Counts of cleaved Caspase-3-positive cells in xenograft nodules. Images were captured from 3–6 slides and 1–2 nodules; at least 5–9 fields and 500–1,500 nuclei for each experimental condition were analyzed. Statistical analysis was performed by unpaired t-test. Data are shown as mean ± standard deviation. Asterisks refer to pairwise comparison of treated samples vs. vehicle group. * p < 0.05; ** p < 0.01; not significant p-values are not shown.