Table 5.

Estimates of time × SNP interaction effects at nine SNPs identified in longitudinal XWAS.

SNP	Trait	ADNI cohort	XCI-R			XCI-E
			Time × SNP	95% CI	p-valueb	Time × SNP	95% CI	p-valueb
rs12157031	FS MidTemp	1/GO/2	59.803	36.738 ~ 82.867	7.73 × 10 −7	89.681	52.564 ~ 126.797	3.82 × 10−6
rs428303	FS Ventriclesa	1/GO/2	−0.006	−0.009 ~ −0.002	6.61 × 10−4	−0.010	−0.014 ~ −0.006	1.29 × 10 −6
rs4829868	FS Ventriclesa	1/GO/2	−0.010	−0.015 ~ −0.006	1.42 × 10−5	−0.017	−0.023 ~ −0.011	3.19 × 10 −8
rs5931111	FS Ventriclesa	1	−0.014	−0.020 ~ −0.008	9.80 × 10−6	−0.022	−0.030 ~ −0.015	1.92 × 10 −8
rs5953487	FS Ventriclesa	1/GO/2	−0.005	−0.008 ~ −0.001	4.14 × 10−3	−0.010	−0.014 ~ −0.006	1.50 × 10 −6
rs10284107	FS Ventriclesa	1/GO/2	−0.006	−0.010 ~ −0.003	3.20 × 10−4	−0.012	−0.017 ~ −0.007	1.19 × 10 −6
rs5955016	FS Ventriclesa	1/GO/2	−0.005	−0.008 ~ −0.002	3.82 × 10−3	−0.010	−0.014 ~ −0.006	1.29 × 10 −6
rs6540385	FS Ventriclesa	1/GO/2	−0.006	−0.009 ~ −0.003	1.26 × 10−4	−0.010	−0.014 ~ −0.006	1.19 × 10 −6
rs763320	FS Ventriclesa	1/GO/2	−0.006	−0.009 ~ −0.003	9.29 × 10−5	−0.010	−0.014 ~ −0.006	5.37 × 10 −7

CI, confidence interval. ^aFS Ventricles is transformed using the rank-based inverse normal transformation. ^bThe p-values less than the significance level of 2.54 ×10^–6 are highlighted in bold.