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. 2023 Oct 5;10(6):3622–3636. doi: 10.1002/ehf2.14532

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© 2023 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The AHR agonist regulates the activation of Akt and p70S6K. (A) Expression of the AHR activation biomarker protein Cyp1a1 in myocardial tissue lysates harvested from peri‐infarct areas of the control, sham, control + ITE1.6, MI, MI + ITE1.6, and MI + ITE8.0 groups (n = 6 per group); the results were compared using two‐way ANOVA. Data are presented as mean ± SD. (B) Expression of Akt/p70S6K signalling pathway proteins, including total Akt (t‐Akt), phosphorylated Akt (P‐Akt), total p70S6K (t‐p70S6K), and phosphorylated p70S6K (P‐p70S6K), in myocardial tissue lysates harvested from peri‐infarct areas of control, sham, control + ITE1.6, MI, MI + ITE1.6, and MI + ITE8.0 (n = 6 per group); the results were compared using two‐way ANOVA. Data are presented as mean ± SD.