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. 2018 Apr 30;145(9):dev162123. doi: 10.1242/dev.162123

Fig. 7.

Fig. 7. A novel self-organizing model of IHBD morphogenesis. In the normal embryo, inductive polarization and lumen expansion initiated by a single cell are synchronized and occur prior to apical constriction. By contrast, over-recruitment of biliary cells to developing IHBD structures may occur as a result of failed coordination between lumen expansion and apical constriction in the absence of NF2 (merlin). Red, moesin; green, Sox9; green striped, obligately polarized; blue, nuclei; asterisk, portal vein.

A novel self-organizing model of IHBD morphogenesis. In the normal embryo, inductive polarization and lumen expansion initiated by a single cell are synchronized and occur prior to apical constriction. By contrast, over-recruitment of biliary cells to developing IHBD structures may occur as a result of failed coordination between lumen expansion and apical constriction in the absence of NF2 (merlin). Red, moesin; green, Sox9; green striped, obligately polarized; blue, nuclei; asterisk, portal vein.