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. 2023 Nov 14;14:1243910. doi: 10.3389/fendo.2023.1243910

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Copyright © 2023 Alufer, Tsaban, Rinott, Kaplan, Meir, Zelicha, Ceglarek, Isermann, Blüher, Stumvoll, Stampfer and Shai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Crude and adjusted correlations between 18-month biomarkers changes and 18-month fasting morning cortisol change. 1. Partial correlation analysis of Δvariable_18months with ΔFMC_18months 2. Crude – univariate correlation of Δvariable_18months with ΔFMC_18months 3. Model 1 – adjusted for: age, gender, and intervention group. 4. Model 2 – adjusted for: age, gender, intervention group and Δweight_18months. 5. Abbreviations: FMC, fasting morning cortisol; BMI, body mass index; BP, blood pressure; HOMA-IR, Homeostatic Model Assessment for Insulin Resistance; HbA1c , glycated-hemoglobin-A1c; LDL ,Low-density lipoprotein cholesterol; HDLc, high density lipoprotein cholesterol; FFA, free -fatty acids; ALT, Alanine Transaminase; AST, Aspartate aminotransferase; ALKP, alkaline phosphatase; hsCRP, High Sensitivity C-Reactive Protein; IL6, Interleukin-6; FGF-21, Fibroblast Growth Factor 21; TSH, Thyroid Stimulating Hormone; VAT, visceral adipose tissue; IHF, intra-hepatic fat. 6. * p≤0.05. 7. All pvalues are corrected for multiple comparisons (FDR-BH, Q=5%).