| 1.1 Hypoglycaemia |
2 |
2548 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.87 [0.79, 0.95] |
| 1.2 Major neurological disability at two years of age |
2 |
1554 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.00 [0.59, 1.68] |
| 1.2.1 Major neurological disability at two years of age |
2 |
1554 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.00 [0.59, 1.68] |
| 1.3 Major neurological disability at six to seven years of age |
1 |
308 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.72 [0.49, 1.06] |
| 1.4 Major neurological disability at two years of age ‐ by risk factor |
1 |
1194 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.45 [0.78, 2.71] |
| 1.4.1 Child of mother with diabetes |
1 |
900 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.10 [0.54, 2.23] |
| 1.4.2 Other risk factor |
1 |
294 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.95 [0.85, 18.27] |
| 1.5 Receipt of treatment for hypoglycaemia during initial hospital stay |
2 |
2548 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.89 [0.79, 1.00] |
| 1.6 Separation from mother for treatment of hypoglycaemia (admission to NICU for hypoglycaemia) |
2 |
2548 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.12 [0.81, 1.55] |
| 1.7 Receipt of intravenous treatment for hypoglycaemia |
2 |
2548 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.01 [0.68, 1.49] |
| 1.8 Adverse effects (e.g. choking or vomiting at time of administration) |
2 |
2510 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.22 [0.64, 2.33] |
| 1.9 Developmental disability at two years of age |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.9.1 Developmental disability at two years of age |
2 |
1553 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.03 [0.84, 1.26] |
| 1.10 Developmental disability at six to seven years of age |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.10.1 Developmental disability at six to seven years of age |
1 |
308 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.85 [0.68, 1.07] |
| 1.11 Any neurological disability at two years of age ‐ by risk factor |
1 |
1194 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.11 [0.88, 1.40] |
| 1.11.1 Child of mother with diabetes |
1 |
900 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.12 [0.87, 1.46] |
| 1.11.2 Other risk factor |
1 |
294 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.07 [0.65, 1.75] |
| 1.12 Any neurological disability at six to seven years of age ‐ by risk factor |
1 |
308 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.84 [0.68, 1.05] |
| 1.12.1 Child of mother with diabetes |
1 |
219 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.80 [0.63, 1.02] |
| 1.12.2 Other risk factor |
1 |
89 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.99 [0.59, 1.68] |
| 1.13 Any neurological disability at six to seven years of age ‐ by single or multiple gel dose |
1 |
308 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.85 [0.68, 1.07] |
| 1.13.1 Single dose |
1 |
167 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.82 [0.61, 1.10] |
| 1.13.2 Multiple dose |
1 |
141 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.90 [0.64, 1.27] |
| 1.14 Receipt of oral dextrose gel treatment for hypoglycaemia |
2 |
2548 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.90 [0.79, 1.01] |
| 1.15 Receipt of any medications for hypoglycaemia such as glucagon or corticosteroids |
2 |
2548 |
Risk Ratio (M‐H, Fixed, 95% CI) |
Not estimable |
| 1.16 Number of episodes of hypoglycaemia (glucose oxidase method) (total number per infant) |
1 |
186 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.18 [‐0.55, 0.19] |
| 1.17 Neonatal seizures |
2 |
2548 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.69 [0.08, 5.69] |
| 1.18 Duration of initial hospital stay (days) |
2 |
2537 |
Mean Difference (IV, Fixed, 95% CI) |
0.06 [‐0.13, 0.24] |
| 1.19 Breastfeeding (any) after discharge |
2 |
2323 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.01 [0.98, 1.05] |
| 1.19.1 Breastfeeding (full or exclusive) after discharge |
2 |
2323 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.01 [0.98, 1.05] |
| 1.20 Visual impairment at two years of age |
2 |
1551 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.19 [0.01, 4.03] |
| 1.21 Hearing impairment at two years of age |
2 |
1551 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.32 [0.05, 2.05] |
| 1.22 Cerebral palsy at two years of age |
2 |
1543 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.49 [0.04, 5.33] |
| 1.23 Developmental delay/intellectual impairment at two years of age |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.23.1 Developmental delay/intellectual impairment at two years of age |
2 |
1546 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.07 [0.86, 1.32] |
| 1.24 Developmental delay/intellectual impairment at two years of age ‐ mild (70 to 84) |
1 |
1187 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.08 [0.82, 1.43] |
| 1.25 Developmental delay/intellectual impairment at two years of age ‐ moderate or severe (< 70) |
1 |
1187 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.87 [0.94, 3.72] |
| 1.26 Developmental delay/intellectual impairment at six to seven years of age |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.26.1 Developmental delay/intellectual impairment at six to seven years of age ‐ motor impairment |
1 |
308 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.25 [0.10, 0.59] |
| 1.26.2 Developmental delay/intellectual impairment at six to seven years of age ‐ language impairment |
1 |
308 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.69 [0.41, 1.17] |
| 1.27 Developmental delay/intellectual impairment at two years of age ‐ by risk factor |
1 |
1194 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.11 [0.88, 1.40] |
| 1.27.1 Child of mother with diabetes |
1 |
900 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.12 [0.87, 1.46] |
| 1.27.2 Other risk factor |
1 |
294 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.07 [0.65, 1.75] |
| 1.28 Executive dysfunction at two years of age |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.28.1 Executive dysfunction at two years of age |
2 |
1544 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.79 [0.54, 1.16] |
| 1.29 Executive dysfunction at six to seven years of age |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.29.1 Executive dysfunction at six to seven years of age |
1 |
308 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.65 [0.35, 1.19] |
| 1.30 Executive dysfunction at six to seven years of age ‐ by single or multiple gel dose |
1 |
308 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.66 [0.36, 1.21] |
| 1.30.1 Single dose |
1 |
167 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.41 [0.20, 0.84] |
| 1.30.2 Multiple dose |
1 |
141 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.34 [0.54, 10.26] |
| 1.31 Executive dysfunction at two years of age ‐ by risk factor |
1 |
1187 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.95 [0.60, 1.50] |
| 1.31.1 Child of mother with diabetes ‐ at two years of age |
1 |
895 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.80 [0.47, 1.35] |
| 1.31.2 Other risk factor ‐ at two years of age |
1 |
292 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.67 [0.62, 4.47] |
| 1.32 Executive dysfunction at six to seven years of age ‐ by risk factor |
1 |
308 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.63 [0.35, 1.16] |
| 1.32.1 Child of mother with diabetes ‐ at six to seven years of age |
1 |
219 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.74 [0.38, 1.45] |
| 1.32.2 Other risk factor ‐ at six to seven years of age |
1 |
89 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.28 [0.05, 1.45] |
| 1.33 Emotional‐behavioural difficulty at six to seven years of age |
1 |
228 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.62 [0.33, 1.18] |
| 1.34 Emotional‐behavioural difficulty at six to seven years of age ‐ by risk factor |
1 |
228 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.61 [0.32, 1.17] |
| 1.34.1 Child of mother with diabetes |
1 |
160 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.55 [0.26, 1.14] |
| 1.34.2 Other risk factor |
1 |
68 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.85 [0.22, 3.25] |
| 1.35 Emotional‐behavioural difficulty at six to seven years of age ‐ by single or multiple gel dose |
1 |
228 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.62 [0.32, 1.19] |
| 1.35.1 Single dose |
1 |
121 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.42 [0.18, 1.01] |
| 1.35.2 Multiple dose |
1 |
107 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.02 [0.35, 2.96] |
