Table 1.
Study population characteristics
| Brugada patients (n = 79) | Negative Ajmaline subjects (n = 44) | P-value | |
|---|---|---|---|
| Clinical characteristics | |||
| Male sex, n (%) | 55 (69.6%) | 28 (63.6%) | 0.64 |
| Age (years) | 47 ± 14 | 36 ± 14 | 0.03 |
| Family history of SCD, n (%) | 15 (18.9%) | 4 (9.1%) | 0.23 |
| Syncope, n (%) | 15 (18.9%) | 8 (18.2%) | 0.91 |
| Previous sustained VAs, n (%) | 7 (8.9%) | — | — |
| Previous ICD implantation, n (%) | 16 (20.2%) | — | — |
| SCN5A P/LP variant, n (%) | 10 (12.6%) | — | — |
| Heart rate (bpm) | 82 ± 12 | 78 ± 10 | 0.83 |
| Echocardiographic parameters | |||
| LVEF (%) | 60.2 ± 2.1 | 60.7 ± 2.8 | 0.91 |
| LA diameter (mm) | 31.5 ± 5.7 | 30.7 ± 6 | 0.74 |
| LAVI (mL/m2) | 25.2 ± 5.1 | 24.8 ± 7.8 | 0.61 |
| RAVI (mL/m2) | 22.8 ± 2.7 | 21.35 ± 6.6 | 0.18 |
| Brugada ECG pattern, n (%) | |||
| Spontaneous Brugada type 1 | 23 (29.1%) | — | — |
| Ajmaline-induced Brugada type 1 | 55 (69.6)% | — | — |
| Fever-induced Brugada type 1 | 1 (1.3%) | — | — |
| Brugada type 2 ECG pattern | 25 (31.2%) | 11 (25%) | 0.56 |
Data are presented as mean ± standard deviation.
α = 0.05.
SCD, sudden cardiac death; VAs, ventricular arrhythmias; P/LP, pathogenic/likely pathogenic; LVEF, left ventricular ejection fraction; LA, left atrial; LAVI, Left atrial volum index; RAVI, right atrial volume index; ECG, electrocardiogram; ICD, implantable cardioverter defibrillator.