Fig. 1.

ARG1 was closely associated with tumor progression and increased immune checkpoints expression on T cells. a ARG1 expression between tumor and normal samples analyzed by TIMER 2.0 (http://timer.cistrome.org/). b The correlation between ARG1 and immune checkpoint ICOS, PD-1, TIGIT and TIM3 in various tumors was analyzed by heat map (p < 0.05). Download TCGA data on TIMER 2.0 (http://timer.cistrome.org/) platform. c Six major immune cell types in MC38 tumors were identified by UMAP analysis. d Feature plots for expression of Arg1 in six kinds of immune cells. e Four main cell types in MPs were identified by UMAP analysis. f Dot plots showing the Arg1 gene expression in four kinds of MPs