Table 2.
Associations between 1-point increment in total adherence score and risk of all cancers combined and of cancer at individual anatomical sites
| Model 1 | Model 2 | |||||
|---|---|---|---|---|---|---|
| Cancer site | Total | Incident cancers | HR (95% CI) | P value | HR (95% CI) | P value |
| All cancers combined | 93,630 | 7296 | 0.92 (0.90; 0.94) | < 0.001a | 0.93 (0.90; 0.95) | < 0.001a |
| Prostate | 43,851 | 1818 | 1.01 (0.96; 1.05) | 0.759 | 1.00 (0.96; 1.05) | 0.959 |
| Breast | 50,337 | 1438 | 0.90 (0.85; 0.95) | < 0.001a | 0.90 (0.86; 0.95) | < 0.001a |
| Pre-menopausal | 1108 | 154 | 0.83 (0.72; 0.96) | 0.014 | 0.83 (0.72; 0.96) | 0.013 |
| Post-menopausal | 49,229 | 1284 | 0.90 (0.85; 0.95) | < 0.001a | 0.90 (0.85; 0.95) | < 0.001a |
| Colorectal | 94,656 | 863 | 0.89 (0.83; 0.95) | 0.001a | 0.90 (0.84; 0.97) | 0.003a |
| Colon | 94,698 | 575 | 0.83 (0.76; 0.90) | < 0.001a | 0.83 (0.77; 0.90) | < 0.001a |
| Distal | 94,734 | 242 | 0.74 (0.65; 0.84) | < 0.001a | 0.75 (0.66; 0.85) | < 0.001a |
| Proximal | 94,748 | 303 | 0.89 (0.80; 1.00) | 0.050 | 0.90 (0.81; 1.01) | 0.074 |
| Rectum | 94,734 | 342 | 1.00 (0.91; 1.12) | 0.878 | 1.03 (0.93; 1.15) | 0.588 |
| Lung | 94,760 | 431 | 0.86 (0.78; 0.94) | < 0.001a | 0.93 (0.84; 1.02) | 0.125 |
| Kidney | 94,754 | 221 | 0.82 (0.72; 0.93) | 0.003a | 0.82 (0.72; 0.94) | 0.004 |
| Pancreas | 94,770 | 213 | 0.87 (0.76; 0.99) | 0.035 | 0.88 (0.77; 1.00) | 0.056 |
| Uterus | 50,588 | 212 | 0.93 (0.81; 1.06) | 0.269 | 0.92 (0.81; 1.05) | 0.227 |
| Oesophagus | 94,765 | 151 | 0.81 (0.69; 0.95) | 0.010 | 0.84 (0.71; 0.98) | 0.031 |
| Ovary | 50,603 | 147 | 0.76 (0.65; 0.90) | 0.001a | 0.76 (0.65; 0.90) | 0.001a |
| Bladder | 94, 756 | 141 | 0.88 (0.74; 1.03) | 0.116 | 0.90 (0.76; 1.07) | 0.240 |
| Head and neck | 94,763 | 129 | 1.17 (0.99; 1.40) | 0.068 | 1.21 (1.02; 1.44) | 0.031 |
| Stomach | 94,770 | 99 | 0.97 (0.79; 1.18) | 0.725 | 0.98 (0.80; 1.19) | 0.830 |
| Liver | 94,773 | 82 | 0.77 (0.62; 0.96) | 0.017 | 0.78 (0.63; 0.97) | 0.024 |
| Gallbladder | 94,777 | 49 | 0.71 (0.54; 0.94) | 0.017 | 0.70 (0.53; 0.93) | 0.013 |
Data are presented as hazard ratio (HR) with 95% confidence intervals in parentheses (95% CIs) per 1-point increment in score. Model 1 was adjusted for age, sex, Townsend deprivation index, and ethnicity, and Model 2 was additionally adjusted for smoking status
aFollowing correction using the Holm-Bonferroni method P < 0.05