Table 4.

Multivariable logistic regression examining the association between sepsis renal angina fulfillment (sRAI +), serum creatinine above baseline on day 1 (D1 SCr > Baseline +), severity of illness and baseline creatinine used on the presence of severe acute kidney injury on day 3 and need for kidney replacement therapy

Outcome	Variable	Adjusted OR	95% CI	P
D3 Severe AKI	PRISM III PERSEVERE-II* Baseline SCr D1 VIS sRAI +  D1 SCr > Baseline +	1.00 1.33 0.09 1.02 4.54 3.2	0.94–1.05 1.06–1.68 0.008–0.91 1.002–1.04 2.03–10.2 1.06–9.8	0.87 0.02 0.04 0.03  < 0.001 0.039
Need for KRT	PRISM III PERSEVERE-II* Baseline SCr D1 VIS sRAI +  D1 SCr > Baseline +	0.92 1.67 1.76 1.03 5.65 0.97	0.85–0.99 1.2–2.3 0.06–48.0 1.01–1.05 1.48–21.5 0.24–3.98	0.036 0.002 0.74 0.002 0.011 0.96

*PERSEVERE-II Mortality Probability transformed by a factor of 10 for regression analyses

**Only included 337 patients (excluded those on KRT on Day 1)

PRISM III–Pediatric Risk of Mortality III; sRAI +—sepsis renal angina criteria fulfilled; D1 SCr > Baseline +—serum creatinine above baseline on Day 1; AKI—acute kidney injury; KRT—kidney replacement therapy; VIS—vasoactive-inotropic score