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. Author manuscript; available in PMC: 2023 Nov 28.
Published in final edited form as: Adv Pharmacol. 2023 Feb 24;97:229–255. doi: 10.1016/bs.apha.2023.01.002

Fig. 1.

Fig. 1

20-HETE receptor signaling. (A) Molecular mechanisms and pathways associated with the pairing of 20-HETE and GPR75 across (1) endothelial cells, (2) vascular smooth muscle cells and (3) adipose tissues. (B) The signaling pathways associated with the pairing of 20-HETE and the free fatty acid receptor (FFAR/GPR40). Glucose drives changes in intracellular calcium that alongside 20-HETE, promotes and enhance increases in glucose-stimulated insulin secretion through the activation of FFAR1/GPR40 in beta cells of the pancreas.