Table 2. Univariate and multivariate Cox regression analysis of overall survival and recurrence-free survival in 374 patients with hepatocellular carcinoma.
| Characteristics | OS | RFS | ||
| HR (95% CI) | *P-value | HR (95% CI) | *P-value | |
| Univariate analysis | ||||
| Age | ||||
| <=60 vs >60 | 0.960 (0.718-1.284) | 0.783 | 1.205 (0.850-1.708) | 0.295 |
| Gender | ||||
| Female vs Male | 0.982 (0.721-1.338) | 0.909 | 0.793 (0.557-1.130) | 0.200 |
| Pathologic stage | ||||
| Stage I&II vs Stage III&IV | 2.201 (1.591-3.046) | <0.001 | 2.504 (1.727-3.631) | <0.001 |
| Tumor status | ||||
| With tumor vs Free tumor | 11.342 (7.567-17.000) | <0.001 | 2.317 (1.590-3.376) | <0.001 |
| Histologic grade | ||||
| G1&G2 vs G4&G3 | 1.152 (0.853-1.557) | 0.355 | 1.091 (0.761-1.564) | 0.636 |
| Adjacent hepatic tissue inflammation | ||||
| None vs Mild&Severe | 1.238 (0.867-1.768) | 0.241 | 1.194 (0.734-1.942) | 0.475 |
| AFP (ng/ml) | ||||
| <=400 vs >400 | 1.045 (0.698-1.563) | 0.832 | 1.075 (0.658-1.759) | 0.772 |
| Child-Pugh grade | ||||
| A vs C&B | 1.395 (0.765-2.545) | 0.277 | 1.643 (0.811-3.330) | 0.168 |
| Vascular invasion | ||||
| Yes vs No | 1.676 (1.196-2.348) | 0.003 | 1.344 (1.012-2.035) | 0.013 |
| CENPB mRNA | ||||
| Low vs High | 1.544 (1.153-2.068) | 0.004 | 1.475 (1.041-2.089) | 0.029 |
| Multivariate analysis | ||||
| Pathologic stage | ||||
| Stage I&II vs Stage III&IV | 1.330 (0.877-2.018) | 0.180 | 2.134 (1.437-3.170) | <0.001 |
| Tumor status | ||||
| With tumor vs Free tumor | 11.821 (7.546-18.519) | <0.001 | 1.863 (1.248-2.782) | 0.002 |
| Vascular invasion | ||||
| Yes vs No | 1.546 (1.065-2.245) | 0.022 | 1.274 (1.221-1.973) | 0.033 |
| CENPB mRNA | ||||
| Low vs High | 1.286 (1.103-1.832) | 0.033 | 1.351 (1.207-1.977) | 0.037 |
Abbreviations: HR, hazard ratio; CI, confidential interval; AFP, alpha fetoprotein; OS, overall survival; RFS, recurrence-free survival. *P-Value<0.05 were considered statistically significant.