Table 3. Correlation between CENPB protein expression and clinicopathologic features in 490 patients with hepatocellular carcinoma.

Characteristics		N	CENPB level		χ2	*P-Value
			High(n)	Low(n)
Age (year)	>50	288	59	229	4.421	0.036
	<=50	202	58	144
Gender	Male	424	104	320	0.733	0.392
	Female	66	13	53
Tumor size (cm)	>5cm	213	78	135	33.657	0.000
	<=5cm	277	39	238
TNM stage	I/II	34	14	20	6.015	0.014
	III	456	103	353
Serum AFP level	>400ng/ml	164	50	114	5.926	0.015
	<=400ng/ml	326	67	259
Liver cirrhosis	Yes	244	53	191	1.243	0.265
	No	246	64	182
Multiple nodules	Yes	85	29	56	5.933	0.015
	No	405	88	317
Tumor differentiation	Poor	41	8	33	0.469	0.493
	Moderate/well	449	109	340
HBsAg	Positive	438	101	337	1.520	0.218
	Negative	52	16	36
Vascular invasion	Yes	229	65	166	4.365	0.037
	No	261	52	207
Tumor encapsulation	Yes	219	31	188	20.592	0.000
	No	271	86	185
Recurrence	Yes	278	86	192	17.609	0.000
	No	212	31	181
Survival status	Alive	178	59	119	13.212	0.000
	Dead	212	58	254