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. 2023 Nov 1;15(21):12120–12135. doi: 10.18632/aging.205168

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Copyright: © 2023 Gong et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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miR-124-3p targeted and repressed USP14. (A) StarBase was employed to analyze the upstream miRNAs of USP14, and a Venn diagram was adopted to analyze the USP14-targeted miRNAs shared by miRmap, microT, miRanda, PicTar, and TargetScan. (B) The binding sites between miR-124-3p and USP14. (C) The targeting correlation between miR-124-3p and USP14 was verified by dual-luciferase reporter assay. (D, E) miR-124-3p mimics were transfected into EC cells, and USP14 mRNA and protein expression was assessed. NS, ^**, ^***represent P > 0.05, P < 0.01, and P < 0.001. N = 3.