Table 1.
Characteristics of the patients treated with or without bridging therapy.
| Bridging therapy N = 255 |
No bridging therapy N = 348 |
p | |
|---|---|---|---|
| Age (mean, years) | 68.9 ± 13.3 | 69.9 ± 12.0 | 0.2 |
| NIHSS on admission (mean, median) | 10.1 ± 7.4 9 (IQR 12) |
7.2 ± 6.5 5 (IQR 9) |
<0.0001 |
| Sex male | 156 (61.2%) | 181 (52.0%) | 0.02 |
| Diabetes Mellitus | 64 (25.1%) | 78 (22.4%) | 0.4 |
| Hypertension | 178 (69.8%) | 252 (72.4%) | 0.5 |
| Hyperlipidemia | 130 (51.0%) | 151 (43.4%) | 0.07 |
| Atrial fibrillation | 118 (46.3%) | 198 (56.9%) | 0.01 |
| History of stroke | 69 (27.1%) | 126 (36.2%) | 0.02 |
| Smoking (ongoing) | 53 (20.8%) | 59 (16.9%) | 0.2 |
| Alcoholism | 34 (13.3%) | 29 (8.3%) | 0.06 |
| Congestive heart failure | 52 (20.4%) | 75 (21.5%) | 0.7 |
| History of myocardial infarction | 46 (18.0%) | 62 (17.8%) | 1.0 |
| Peripheral artery disease | 31 (12.1%) | 32 (9.2%) | 0.3 |
| Pacemaker | 32 (12.5%) | 48 (13.8%) | 0.7 |
| Lesion size | 0.002 | ||
| Small | 96 (37.6%) | 181 (52.0%) | |
| Medium | 91 (35.7%) | 101 (29.0%) | |
| Large | 68 (26.7%) | 66 (19.0%) | |
| Hemorrhagic transformation (24–72 h) | 44 (17.2%) | 54 (15.5%) | 0.6 |
| Intracardiac thrombus | 19 (7.4%) | 17 (4.9%) | 0.2 |
| Mechanical mitral valve | 115 (45.1%) | 144 (41.4%) | 0.5 |
| Mechanical aortic valve | 114 (44.7%) | 172 (49.4%) | 0.3 |
| Mechanical mitral and aortic valves | 26 (10.2%) | 33 (9.5%) | 0.8 |
| rtPA | 43 (16.9%) | 29 (8.3%) | 0.002 |
| rtPA and/or mechanical thrombectomy | 97 (38.0%) | 59 (16.9%) | <0.0001 |
| Antiplatelet on admission | 85 (33.3%) | 94 (27.0%) | 0.1 |
| INR ⩾ 2.5 on admission | 45 (17.6%) | 106 (30.4%) | <0.0001 |
| Creatinine clearance | 77.2 ± 36.6 | 67.9 ± 25.4 | <0.0001 |
| Antiplatelet at discharge | 12 (4.7%) | 30 (8.6%) | 0.08 |
| Timing of anticoagulant therapy initiation (mean, days) | 3.3 ± 2.6 | 3.5 ± 7.6 | 0.6 |
IQR: interquartile range.