TABLE 3.

Factors that may contribute to clinical antifungal drug resistance

Fungal factors	Drug factors	Host (and other) factors
Initial MIC	Fungistatic nature of drug	Immune status
Cell type	Dosing	Site of infection
Yeast/hyphae	Frequency	Severity of infection
Switch phenotype	Quantity	Presence of foreign materials (dentures, catheters, prosthetic valves)
Serotype	Schedule (intermittent vs continuous)	Abscess formation
Genomic stability of strain	Cumulative dose	Patient noncompliance with drug regimen
Size of population	Pharmacokinetics
Population “bottlenecks”	Absorption
Biofilms	Distribution
	Metabolism
	Drug-drug interactions