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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: J Med Virol. 2023 Nov;95(11):e29244. doi: 10.1002/jmv.29244

Table 2: Existing PCNA inhibitors.

There are currently 3 peptide and 4 small molecular inhibitors of PCNA. They prevent the assembly of the PCNA trimer or PCNA:target protein interactions.

Name Target Type Reference
T2AA PCNA-PIP Box Small Molecule Punchihewa et al 2012
PCNA-I1 PCNA Trimers Small Molecule Tan et al 2012
AOH1160 ca-PCNA Small Molecule Gu et al 2018
AOH1996 ca-PCNA Small Molecule Gu et al 2023
p21C2 p21-PCNA interaction Peptide Chen et al 1996
p21PBP p21-PCNA interaction Peptide Warbrick et al 1995
Y211F CPPP PCNA phosphorylation Peptide Zhao et al 2011
Con1-Spop PCNA Peptide Chang et al 2022