Table 1. Plasma biochemical parameters and hormones in the groups fed a low phosphorus diet at the end of the experiment.
LP | LP-Rap | NxLP | NxLP-Rap | |
---|---|---|---|---|
Calcium, mg/dl | 9.7 ± 0.1 | 9.8 ± 0.3 | 8.2 ± 0.2a | 9.4 ± 0.2a |
Phosphorus, mg/dl | 7.9 ± 0.7 | 7.1 ± 0.4 | 7.7 ± 0.3 | 6.8 ± 0.3 |
Creatinine, mg/dl | 0.53 ± 0.01 | 0.59 ± 0.01 | 0.93 ± 0.04a | 1.05 ± 0.07a |
Urea, mg/dl | 31.0 ± 1.6 | 29.7 ± 1.7 | 62.3 ± 5.1a | 81.6 ± 7.9a* |
Cystatin C (ng/ml) | 1315 ± 59 | 1212 ± 27 | 2496 ± 151a | 2650 ± 171a |
FGF23, pg/ml | 310 ± 30 | 205 ± 19a* | 641 ± 423 | 1201 ± 319 a |
PTH, pg/ml | 131.6 ± 15.5 | 141.3 ± 39.2 | 386.4 ± 64.0a | 315.6 ± 73.1 |
FGF23, fibroblast growth factor 23; LP, rats with intact renal function fed a low phosphorus diet; LP-Rap, rats with intact renal function fed a low phosphorus diet and treated with rapamycin; NxLP, nephrectomized rats fed a low phosphorus diet; NxLP-Rap, nephrectomized rats fed a low phosphorus diet and treated with rapamycin; PTH, parathyroid hormone. Values are means ± SE.
ap < 0.05 vs LP
*p < 0.05 vs its placebo counterpart.