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. 2023 Nov 28;18(11):e0294791. doi: 10.1371/journal.pone.0294791

Table 1. Plasma biochemical parameters and hormones in the groups fed a low phosphorus diet at the end of the experiment.

LP LP-Rap NxLP NxLP-Rap
Calcium, mg/dl 9.7 ± 0.1 9.8 ± 0.3 8.2 ± 0.2a 9.4 ± 0.2a
Phosphorus, mg/dl 7.9 ± 0.7 7.1 ± 0.4 7.7 ± 0.3 6.8 ± 0.3
Creatinine, mg/dl 0.53 ± 0.01 0.59 ± 0.01 0.93 ± 0.04a 1.05 ± 0.07a
Urea, mg/dl 31.0 ± 1.6 29.7 ± 1.7 62.3 ± 5.1a 81.6 ± 7.9a*
Cystatin C (ng/ml) 1315 ± 59 1212 ± 27 2496 ± 151a 2650 ± 171a
FGF23, pg/ml 310 ± 30 205 ± 19a* 641 ± 423 1201 ± 319 a
PTH, pg/ml 131.6 ± 15.5 141.3 ± 39.2 386.4 ± 64.0a 315.6 ± 73.1

FGF23, fibroblast growth factor 23; LP, rats with intact renal function fed a low phosphorus diet; LP-Rap, rats with intact renal function fed a low phosphorus diet and treated with rapamycin; NxLP, nephrectomized rats fed a low phosphorus diet; NxLP-Rap, nephrectomized rats fed a low phosphorus diet and treated with rapamycin; PTH, parathyroid hormone. Values are means ± SE.

ap < 0.05 vs LP

*p < 0.05 vs its placebo counterpart.