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. 2023 Nov 28;12:RP88183. doi: 10.7554/eLife.88183

Figure 7. The cellular source of osteoclastogenic cytokines: macrophage-colony stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-Β ligand (RANKL) in the ligature-induced model and the maxillary topical application (MTA) model.

Figure 7.

(A) Violin plots showing expression levels of the M-CSF-encoding gene, Csf1 (M-CSF), in each major cell type from the ligature-induced periodontitis model. (B) Violin plots showing expression levels of Csf1 in fibroblast subpopulations, myeloid cell subpopulations, and T cell subpopulations. (C) Violin plots showing expression levels of the RANKL-encoding gene, Tnfsf11, in each major cell type. (D) Violin plots showing expression levels of Tnfsf11 in fibroblast subpopulations, myeloid cell subpopulations, and T cell subpopulations. (E) Violin plots of Csf1-expressing cells in the MTA model. (F) Violin plots of Tnfsf11-expressing cells in the MTA model. AG fibroblasts predominantly expressed Tnfsf11.