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. 2023 Mar 1;601(7):1207–1224. doi: 10.1113/JP284270

Figure 8. Effects of d‐β‐hydroxybutyrate (βHB) oxidation on energetic parameters in low and high glycogen hearts measured using 31P‐NMR spectroscopy.

Figure 8

A, ATP. B, phosphocreatine (PCr). C, inorganic phosphate (Pi). D, cytosolic pH. E, ADP. F, AMP. G, phosphorylation potential (estimated as [ATP]/[Pi].[ADP]). H, free energy of ATP hydrolysis (ΔG ATP). Data are means ± SD. Data analysis by ANOVA and Tukey correction: A, P: LG +Gluc vs. LG +βHB: 0.866; LG +Gluc vs. HG +Gluc: 0.810; LG +βHB vs. HG +βHB: 0.941; HG +Gluc vs. HG +βHB: 0.883. B, P: LG +Gluc vs. LG +βHB: 0.818; LG +Gluc vs. HG +Gluc: 0.784; LG +βHB vs. HG +βHB: <0.0001; HG +Gluc vs. HG +βHB: 0.016. C, P: LG +Gluc vs. LG +βHB: 0.161; LG +Gluc vs. HG +Gluc: 0.193; LG +βHB vs. HG +βHB: 0.022; HG +Gluc vs. HG +βHB: 0.789. D, P: LG +Gluc vs. LG +βHB: 0.999; LG +Gluc vs. HG +Gluc: 0.250; LG +βHB vs. HG +βHB: 0.553; HG +Gluc vs. HG +βHB: 0.907. E, P: LG +Gluc vs. LG +βHB: 0.201; LG +Gluc vs. HG +Gluc: 0.249; LG +βHB vs. HG +βHB: 0.021; HG +Gluc vs. HG +βHB: 0.009. F, P: LG +Gluc vs. LG +βHB: 0.168; LG +Gluc vs. HG +Gluc: 0.189; LG +βHB vs. HG +βHB: 0.017; HG +Gluc vs. HG +βHB: 0.003. G, P: LG +Gluc vs. LG +βHB: 0.609; LG +Gluc vs. HG +Gluc: 0.049; LG +βHB vs. HG +βHB: 0.011; HG +Gluc vs. HG +βHB: 0. 051. H, P: LG +Gluc vs. LG +βHB: 0.889; LG +Gluc vs. HG +Gluc: 0.776; LG +βHB vs. HG +βHB: 0.012; HG +Gluc vs. HG +βHB: 0.038. The effect of glycogen content is indicated as: *P < 0.05, ***P < 0.001; the effect of βHB is indicated as: # P < 0.05, ## P < 0.01. +βHB, perfusion with glucose + βHB; +Gluc, perfusion with glucose alone; LG, low glycogen; HG, high glycogen.