Table 3.
Effect of myco-fabricated ZnO-NPs on changes in pro-inflammatory cytokines and transaminase enzymes in the brain of mice induced by AlCl3
| Parameters | Groups | F value | p value | |||||
|---|---|---|---|---|---|---|---|---|
| G1 | G2 | G3 | G4 | G5 | G6 | |||
| TNF- α (pg/ml) | 74.4 ± 2.51d | 287.0 ± 4.53a | 75.6 ± 4.83d | 76.4 ± 8.21d | 108.0 ± 7.97c | 124.8 ± 3.89b | 1037.02 | ≤ 0.001 |
| % of changes | 285.7 | 1.61 | 2.69 | 45.16 | 67.74 | |||
| IL1B (pg/ml) | 282.0 ± 14.83d | 418.0 ± 23.87a | 225.0 ± 11.18e | 236.8 ± 17.06e | 336.0 ± 23.02c | 384.0 ± 15.16b | 94.92 | ≤ 0.001 |
| % of changes | 48.23 | −20.21 | −16.03 | 19.15 | 36.17 | |||
| AST(U/L) | 34.0 ± 0.36a | 11.4 ± 0.14d | 33.0 ± 0.21a | 34.4 ± 0.32a | 27.2 ± 0.16b | 16.4 ± 0.29c | 74.29 | ≤ 0.001 |
| % of changes | −66.47 | −2.94 | 1.18 | −20 | −51.76 | |||
| ALT (U/L) | 11.86.0 ± 0.85a | 3.6 ± 0.32d | 12.20 ± 1.68a | 10.98 ± 0.58a | 8.86 ± 0.98b | 5.28 ± 0.77c | 70.41 | ≤ 0.001 |
| % of changes | −69.65 | 2.86 | −7.41 | −25.29 | −55.48 | |||
The mean and standard deviation of ten mice from each group are used to represent the values. Means with different superscripts within the same row differ significantly at (p ≤ 0.05)