Table 2.
Clinical Characteristics of Propensity Score-matched Pairs of Subjects in Protocol 2.
| Variables | Control (n = 18) | Nonfunctioning adrenal adenomas (n = 18) | P value |
|---|---|---|---|
| Age, year | 65 ± 14 | 65 ± 10 | 0.92 |
| Sex, men/women | 13/5 | 14/4 | 0.70 |
| Body mass index, kg/m2 | 26.1 ± 4.7 | 25.8 ± 2.6 | 0.85 |
| Systolic blood pressure, mmHg | 137 ± 15 | 134 ± 15 | 0.56 |
| Diastolic blood pressure, mmHg | 83 ± 12 | 79 ± 11 | 0.37 |
| Heart rate, bpm | 71 ± 12 | 74 ± 12 | 0.55 |
| Total cholesterol, mmol/L | 4.60 ± 1.09 | 4.84 ± 0.72 | 0.47 |
| Triglycerides, mmol/L | 1.75 ± 1.52 | 1.93 ± 1.61 | 0.76 |
| High-density lipoprotein cholesterol, mmol/L | 1.42 ± 0.52 | 1.32 ± 0.49 | 0.57 |
| Low-density lipoprotein cholesterol, mmol/L | 2.64 ± 0.83 | 2.84 ± 0.62 | 0.41 |
| Glucose, mmol/L | 6.94 ± 1.61 | 6.11 ± 1.11 | 0.09 |
| Hemoglobin A1c, % | 6.2 ± 0.9 | 5.9 ± 0.8 | 0.44 |
| Blood urea nitrogen, mmol/L | 5.00 ± 1.43 | 5.36 ± 1.79 | 0.43 |
| Creatinine, μmol/L | 63.65 ± 13.26 | 76.02 ± 13.26 | 0.07 |
| Current smoker, n (%) | 1 (5.6) | 3 (16.7) | 0.28 |
| Medical history, n (%) | |||
| Hypertension | 15 (83.3) | 15 (83.3) | 1.00 |
| Dyslipidemia | 11 (61.1) | 11 (61.1) | 1.00 |
| Diabetes mellitus | 4 (22.2) | 4 (22.2) | 1.00 |
| Previous coronary heart disease | 0 (0.0) | 0 (0.0) | N/A |
| Previous stroke | 1 (5.6) | 3 (16.7) | 0.28 |
| Medication, n (%) | |||
| Calcium channel blockers | 11 (61.1) | 8 (44.4) | 0.32 |
| Angiotensin-converting enzyme inhibitors | 0 (0.0) | 0 (0.0) | 1.00 |
| Angiotensin II receptor blockers | 3 (16.7) | 6 (33.3) | 0.24 |
| Mineralocorticoid receptor blockers | 0 (0.0) | 0 (0.0) | N/A |
| Beta-blockers | 3 (16.7) | 1 (5.6) | 0.28 |
| Alpha-blockers | 0 (0.0) | 1 (5.6) | 0.23 |
| Statins | 6 (27.8) | 5 (27.8) | 0.72 |
| Nitrates | 0 (0.0) | 0 (0.0) | N/A |
| Medically treated diabetes mellitus | |||
| Any | 2 (11.1) | 1 (5.6) | 0.54 |
| Insulin-dependent | 0 (0.0) | 0 (0.0) | N/A |
| Flow-mediated vasodilation, % | 3.4 ± 2.4 | 2.4 ± 1.9 | 0.19 |
| Nitroglycerine-induced vasodilation, % | 13.6 ± 4.6 | 12.1 ± 4.2 | 0.35 |
N/A indicates not applicable.
Results are presented as means ± SD for continuous variables and percentages for categorical variables.