Table 4.
Clinico-pathological associations of ATM mutant breast cancer patients.
| Clinico-pathological variables | ATM mutant (n = 6) | ATM wildtype (n = 709) | p value |
|---|---|---|---|
| n (%) | n (%) | ||
| Age at diagnosis, years | |||
| Mean ± SD | 45 ± 12.7 | 41.2 ± 9.8 | |
| Median (range) | 39 (32 – 63) | 39.7 (13 – 84) | |
| ≤ 50 | 4 (66.7) | 610 (86.0) | 0.2027 |
| > 50 | 2 (33.3) | 99 (14.0) | |
| Family history of breast cancer | |||
| No | 2 (33.3) | 580 (81.8) | 0.0127 |
| Yes | 4 (66.7) | 129 (18.2) | |
| Bilateral breast cancer | |||
| Yes | 0 | 12 (1.7) | 1.0000 |
| No | 6 (100.0) | 697 (98.3) | |
| Lymph node status | |||
| Negative | 2 (33.3) | 258 (37.5) | 1.0000 |
| Positive | 4 (66.7) | 430 (62.5) | |
| Distant metastasis | |||
| Absent | 5 (83.3) | 623 (90.5) | 0.4522 |
| Present | 1 (16.7) | 65 (9.5) | |
| Stage | |||
| I | 0 | 98 (14.2) | 0.7233 |
| II | 3 (20.0) | 282 (41.0) | |
| III | 2 (33.3) | 243 (35.3) | |
| IV | 1 (16.7) | 65 (9.5) | |
| Histologic grade | |||
| Well differentiated | 0 | 48 (7.1) | 0.2026 |
| Moderately differentiated | 5 (83.3) | 317 (47.0) | |
| Poorly differentiated | 1 (16.7) | 309 (45.9) | |
| Estrogen receptor status | |||
| Positive | 5 (83.3) | 388 (57.2) | 0.2479 |
| Negative | 1 (16.7) | 290 (42.8) | |
| Progesterone receptor status | |||
| Positive | 4 (66.7) | 356 (52.6) | 0.6889 |
| Negative | 2 (33.3) | 321 (47.4) | |
| Her-2 neu status | |||
| Positive | 2 (33.3) | 231 (34.6) | 1.0000 |
| Negative | 4 (66.7) | 437 (65.4) | |