Table 1.
Clinical, radiological and biochemical data of the study population.
| Total (n = 30) | 3-month mRS 0–2 (n = 10) | 3-month mRS 3–6 (n = 20) | p-value | |
|---|---|---|---|---|
| Females/males | 17/13 | 5/5 | 12/8 | 0.602 |
| Age (years) | 75.1 (± 11.3) | 75.5 (± 9.4) | 75.0 (± 12.4) | 0.974 |
| Time from onset to blood sampling | 22 h 40 m (18 h 45 m–23 h 04 m) | 20 h 53 m (15 h 38 m–24 h 8 m) | 23 h 30 m (19 h 30 m–27 h 30 m) | 0.140 |
| Previous neurological diseases* (yes/no) | 5/25 | 2/8 | 3/17 | 0.729 |
| ASPECTS at admission | 7 (7–8) | 9 (7.5–9) | 7 (6–8) | 0.015 |
| NIHSS at admission | 14.0 (10.0–17.0) | 13.0 (8.8–16.3) | 14.0 (10.3–17.0) | 0.656 |
| Thrombectomy (yes/no) | 27/3 | 9/1 | 18/2 | 1.00 |
| Intravenous thrombolysis (yes/no) | 11/19 | 5/5 | 6/14 | 0.284 |
| ASPECTS after 24–72 h | 7 (5–8) | 7.5 (7–8.75) | 6.5 (5–7) | 0.061 |
| NIHSS score change within 24 h | 3 (− 2.5 to 9) | − 1 (− 3.75 to 3) | 9 (7.5–12.3) | 0.0001 |
| 24 h NIHSS | 10.0 (4.3–14.8) | 1.5 (0.8–6.3) | 12.5 (8.3–21.5) | < 0.0001 |
| 48 h NIHSS | 9.0 (1.0–14.0) | 0.5 (0.0–4.0) | 11.0 (9.0–22.0) | < 0.0001 |
| 72 h NIHSS | 6.0 (1.0–14.0) | 1.0 (0.0–3.3) | 12.0 (6.0–26.0) | < 0.0001 |
| NIHSS at discharge | 3.0 (1.0–7.8) | 0.5 (0.0–2.5) | 7.5 (2.5–13.3) | 0.0005 |
| mRS at discharge | 4.0 (1.3–5.8) | 1.0 (1.0–2.5) | 5.0 (4.0–6.0) | < 0.0001 |
| mRS after 90 days | 4.0 (1.3–6.0) | 1.0 (1.0–2.3) | 5.5 (4.0–6.0) | < 0.0001 |
| Creatinine (mg/dl) | 0.855 (0.740–1.213) | 0.915 (0.773–1.060) | 0.815 (0.710–1.250) | 0.860 |
| β-syn (pg/ml) | 20.1 (5.8–43.8) | 4.8 (1.9–25.1) | 32.6 (9.2–94.4) | 0.0023 |
| NfL (pg/ml) | 50.4 (34.0–113.1) | 34.4 (19.3–49.8) | 76.6 (42.1–178.8) | 0.0011 |
| GFAP (ng/ml) | 6.3 (1.0–20.5) | 0.5 (0.2–7.1) | 9.2 (5.3–21.8) | 0.0045 |
Age is reported as mean ± standard deviation, other continuous variables as median (interquartile range).
*1 dementia, 1 Parkinson’s disease, 1 previous stroke, 2 delirium.