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Accuracy and precision obtained from the analysis of human plasma quality control samples spiked with bosentan and its metabolite analysed by LC-MRM CID. LOQQC limit of quantification QC, LQC low QC, MQC medium QC, HQC high QC used for calibration range 0.5 to 500 ng/mL
| Amount added (ng/mL) | Bosentan | Desmethyl bosentan | n | |||
|---|---|---|---|---|---|---|
| CV (%) | Accuracy (%) | CV (%) | Accuracy (%) | |||
| LOQQC1 | 0.5 | 8.6 | 91.9 | 7.1 | 91.5 | 5 |
| LQC1 | 1.5 | 4.9 | 97.9 | 6 | 99.6 | 5 |
| MQC1 | 50 | 5.5 | 97.4 | 2.8 | 100 | 5 |
| HQC1 | 500 | 2.9 | 90.4 | 1.8 | 96.1 | 5 |
