Figure 1.

Demographics of polytrauma (ISS ≥ 15) patients. Overview of patient’s parameters post-trauma, including ISS score, days in ICU, days with invasive ventilation, and ASA classification (if available), in addition to age and gender distribution. A total of 61 polytrauma patients with internal organ damage (polytrauma OD, n = 32) and polytrauma patients without internal organ damage (polytrauma w/o OD, n = 29) were included in this human study in agreement with the given regulations of the responsible State Chambers of Medicine in Rhineland-Palatinate, Germany (ANr.: 2020-15050). Polytrauma OD includes subgroups such as lacerated parenchymal internal organs such as the liver and spleen, kidney rupture, severe lung contusion, vascular dissection of the aorta, and amputation. Amputation was added to the internal organ damage group due to its severity and strain on the amputee regarding blood loss and pathogen infiltration. For further details, see Supplementary Table 1. ISS, injury severity score; ICU, intensive care unit; ASA, American Society of Anesthesiologists.