Table 4.
Subgroup interaction analysis on the impact of BPD on death or NDI in preterm infants without severe brain injury at 3 years of age.
| Subgroups | Non-BPD | BPD | OR(95% CI) | Interaction p-value |
|---|---|---|---|---|
| Gestational age | ||||
| < 28 weeks | 5/51 (9.8)* | 15/56 (26.8) | 3.366 (1.125–10.073) | |
| 28–296/7 weeks | 37/367 (10.1)*** | 40/192 (20.8) | 2.347 (1.443–3.818) | |
| 30–32 weeks | 32/456 (7.0) | 10/89 (11.2) | 1.677 (0.793–3.549) | |
| Total | 2.583 (1.802–3.705) | 0.563 | ||
| Birth weight | ||||
| < 1,000 g | 6/67 (9.0)* | 14/62 (22.6) | 2.965 (1.060–8.293) | |
| 1,000–1,499 g | 51/549 (9.3)*** | 48/257 (18.7) | 2.243 (1.465–3.434) | |
| ≥ 1,500 g | 17/258 (6.6) | 3/18 (16.7) | 2.835 (0.747–10.759) | |
| Total | 2.583 (1.802–3.705) | 0.853 | ||
| Sex | ||||
| Male | 47/477 (9.9)*** | 44/212 (20.8) | 2.396 (1.531–3.751) | |
| Female | 27/397 (6.8)** | 21/125 (16.8) | 2.767 (1.503–5.094) | |
| Total | 2.583 (1.802–3.705) | 0.709 | ||
BPD, bronchopulmonary dysplasia; OR, odds radio; CI, confidence interval. NDI, neurodevelopmental impairment. Mantel–Haenszel test was used for interaction analysis. *p < 0.05, **p < 0.01, ***p < 0.001.