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. 2023 Nov 15;14:1286700. doi: 10.3389/fimmu.2023.1286700

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Copyright © 2023 Emde-Rajaratnam, Beck, Benes, Salwender, Bertsch, Scheid, Hänel, Weisel, Hielscher, Raab, Goldschmidt, Jauch, Maes, De Bruyne, Menu, De Veirman, Moreaux, Vanderkerken, Seckinger and Hose

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNA-sequencing based determination of proliferation (RPI) (A) of malignant plasma cells from MGUS-, asymptomatic (AMM), symptomatic (MM) and relapsed myeloma patients (MMR) in comparison to normal bone marrow plasma cells (BMPC), memory B-cells (MBC), proliferating plasmablasts (PPC), and human myeloma cell lines (HMCL). Significant differences in comparison to MM are depicted by asterisks (*** P<.001, ** P<0.01). (B) Overall survival and (C) event- free survival. Depicted are Kaplan Maier curves with log-rank based P-value and patients at risk.