Figure 6.

Quantification of LAMP1-, GFAP-, and CD68-positive cells in brain

Quantification of LAMP1 (A and B), GFAP (C and D), and CD68 (E and F) in total brain (A, C, and E) and in different brain areas (B, D, and F). Data represent means ± SEM. In (A), (C), and (E) data were analyzed by one-way ANOVA with Bonferroni’s correction. In (B), (D), and (F) data were analyzed by two-way ANOVA with Bonferroni’s correction, using treatment (IDSco, IDS.IGF2co, IDS.ApoE2co, or IDS.RAP12x2co) and brain areas as categorical variables. Asterisks represent significance vs. WT; hashs represent significance vs. Ids^y/−. Other significant comparisons are indicated by brackets. n = 3. ∗p ≤ 0.05, ∗∗p ≤ 0.01, ∗∗∗p ≤ 0.001, ∗∗∗∗p ≤ 0.0001. #p ≤ 0.05, ##p ≤ 0.01, ###p ≤ 0.001, ####p ≤ 0.0001.