Table 3.
Quantification of mRNA counts and ribosome-protected mRNA fragments (RPFs) in selected pathways
| Acetogen | Dataset | MDN(log2(RNA)) |
MAD(log2(RNA)) |
Mdn(log2(RPF)) |
MDN(log2(RPF)) |
RNA vs. RPF (p value) |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AUTO | HETERO | AUTO | HETERO | AUTO | HETERO | AUTO | HETERO | AUTO | HETERO | ||
| WLP carbonyl branch | |||||||||||
| A. woodii | Shin et al.45 | 12.42 | 10.38 | 2.31 | 1.37 | 14.19 | 14.81 | 1.54 | 1.28 | 0.03 | 5.41e-06 |
| A. woodii | Song et al.44 | 11.98 | 10.07 | 2.43 | 1.60 | 13.80 | 14.46 | 1.53 | 1.46 | 0.04 | 2.17e-05 |
| E. limosum | Song et al.46 | 13.59 | 9.48 | 1.13 | 0.58 | 14.51 | 14.15 | 2.13 | 1.61 | 0.04 | 2.06e-05 |
| E. limosum | Song et al.44 | 12.15 | 9.90 | 1.19 | 0.59 | 14.51 | 14.16 | 2.13 | 1.62 | 3.90e-03 | 2.42e-04 |
| C. drakei | Song et al.44 | 14.66 | 12.36 | 1.08 | 1.03 | 10.72 | 9.53 | 2.09 | 0.90 | 0.03 | 2.30e-03 |
| C. ljungdahlii | Al-Bassam et al.24 | 11.16 | 11.32 | 2.64 | 1.67 | 10.97 | 10.20 | 3.50 | 4.28 | 0.51 | 0.62 |
| Formate dehydrogenase | |||||||||||
| A. woodii | Shin et al.45 | 9.67 | 7.15 | 2.75 | 1.49 | 11.97 | 9.91 | 2.04 | 2.13 | 0.10 | 0.05 |
| A. woodii | Song et al.44 | 9.24 | 6.71 | 2.97 | 1.94 | 11.39 | 9.39 | 2.25 | 1.98 | 0.10 | 0.05 |
| E. limosum | Song et al.46 | 7.78 | 5.44 | 1.14 | 0.87 | 7.14 | 7.20 | 0.97 | 0.06 | 0.50 | 0.20 |
| E. limosum | Song et al.44 | 6.11 | 5.86 | 0.60 | 0.88 | 7.13 | 7.20 | 0.96 | 0.06 | 0.20 | 0.20 |
| C. drakei | Song et al.44 | 12.84 | 10.01 | 0.28 | 1.72 | 9.82 | 7.21 | 0.41 | 0.60 | 0.05 | 0.05 |
| C. ljungdahlii | Al-Bassam et al.24 | 10.47 | 7.91 | 0.64 | 1.23 | 10.52 | 7.58 | 1.07 | 0.51 | 0.50 | 0.50 |
| WLP methyl branch | |||||||||||
| A. woodii | Shin et al.45 | 11.33 | 8.71 | 0.57 | 1.10 | 13.74 | 13.03 | 0.93 | 1.20 | 1.00e-03 | 1.10e-03 |
| A. woodii | Song et al.44 | 9.34 | 7.08 | 2.86 | 1.14 | 11.73 | 10.57 | 1.91 | 1.11 | 0.05 | 0.03 |
| E. limosum | Song et al.46 | 11.22 | 11.14 | 1.69 | 1.62 | 14.32 | 12.63 | 1.12 | 1,19 | 3.97e-03 | 0.05 |
| E. limosum | Song et al.44 | 12.13 | 11.56 | 0.94 | 1.61 | 14.31 | 12.63 | 1.12 | 1.18 | 0.02 | 0.08 |
| C. drakei | Song et al.44 | 14.20 | 11.83 | 0.12 | 0.30 | 9.43 | 8.43 | 1.88 | 0.67 | 3.97e-03 | 3.97e-03 |
| C. ljungdahlii | Al-Bassam et al.24 | 12.59 | 11.77 | 0.38 | 0.37 | 11.45 | 11.81 | 0.85 | 1.44 | 0.03 | 0.42 |
| Rnf complex | |||||||||||
| A. woodii | Shin et al.45 | 9.83 | 8.73 | 0.45 | 0.27 | 11.66 | 11.68 | 0.81 | 0.52 | 1.00e-03 | 1.00e-03 |
| A. woodii | Song et al.44 | 9.38 | 8.43 | 0.57 | 0.42 | 11.22 | 11.26 | 0.83 | 0.68 | 1.00e-03 | 1.00e-03 |
| E. limosum | Song et al.46 | 10.34 | 7.47 | 1.34 | 0.91 | 11.58 | 10.86 | 1.03 | 0.51 | 0.05 | 1.00e-03 |
| E. limosum | Song et al.44 | 8.25 | 7.89 | 0.98 | 0.92 | 11.58 | 10.87 | 1.03 | 0.51 | 1.00e-03 | 4.00e-03 |
| C. drakei | Song et al.44 | 11.17 | 8.15 | 1.42 | 1.32 | 3.79 | 7.31 | 0.60 | 1.20 | 2.00e-03 | 0.15 |
| C. ljungdahlii | Al-Bassam et al.24 | 11.63 | 9.83 | 0.18 | 0.63 | 11.99 | 10.16 | 0.14 | 0.40 | 0.15 | 0.41 |
| ATP synthase complex | |||||||||||
| A. woodii | Shin et al.45 | 10.64 | 8.39 | 1.42 | 0.81 | 11.40 | 11.77 | 1.03 | 1.19 | 0.03 | 1.42e-06 |
| A. woodii | Song et al.44 | 9.99 | 7.88 | 1.90 | 0.75 | 11.06 | 11.23 | 1.38 | 1.62 | 0.05 | 2.16e-05 |
| E. limosum | Song et al.46 | 11.14 | 7.95 | 2.33 | 1.74 | 12.30 | 11.63 | 1.27 | 1.40 | 0.07 | 3.47e-05 |
| E. limosum | Song et al.44 | 10.26 | 8.37 | 1.67 | 1.72 | 12.29 | 11.63 | 1.27 | 1.40 | 3.70e-04 | 5.35e-05 |
| C. drakei | Song et al.44 | 12.93 | 11.76 | 2.02 | 2.45 | 4.27 | 9.16 | 2.08 | 1.45 | 1.50e-04 | 0.04 |
| C. ljungdahlii | Al-Bassam et al.24 | 10.36 | 12.33 | 0.30 | 0.37 | 8.31 | 9.05 | 1.54 | 0.77 | 7.77e-05 | 7.77e-05 |
| Bifurcating hydrogenase | |||||||||||
| A. woodii | Shin et al.45 | 10.38 | 9.11 | 2.31 | 1.04 | 12.5 | 11.03 | 0.53 | 0.31 | 0.03 | 4.00e-03 |
| A. woodii | Song et al.44 | 9.94 | 8.76 | 2.73 | 1.10 | 12.12 | 10.87 | 0.68 | 0.84 | 0.05 | 4.00e-03 |
| E. limosum | Song et al.46 | 10.93 | 8.83 | 2.26 | 1.50 | 13.62 | 10.67 | 0.63 | 1.02 | 4.00e-03 | 0.02 |
| E. limosum | Song et al.44 | 9.50 | 9.25 | 1.14 | 1.51 | 13.78 | 10.86 | 0.88 | 1.20 | 4.00e-03 | 0.05 |
| C. drakei | Song et al.44 | 13.29 | 6.24 | 1.91 | 3.08 | 7.18 | 3.17 | 1.10 | 1.15 | 1.00e-03 | 0.03 |
| C. ljungdahlii | Al-Bassam et al.24 | 10.66 | 9.62 | 0.36 | 0.57 | 11.87 | 10.96 | 0.46 | 0.65 | 0.06 | 0.06 |
| Lactate oxidation | |||||||||||
| A. woodii | Shin et al.45 | 7.86 | 8.02 | 0.65 | 0.90 | 13.77 | 8.43 | 0.94 | 1.38 | 1.00e-03 | 0.19 |
| A. woodii | Song et al.44 | 7.41 | 7.78 | 0.80 | 1.03 | 13.28 | 7.89 | 0.99 | 1.,38 | 1.00e-03 | 0.29 |
| E. limosum | Song et al.46 | 5.57 | 4.43 | 1.62 | 1.48 | 10.30 | 8.94 | 0.10 | 0.47 | 3.00e-03 | 0.13 |
| E. limosum | Song et al.44 | 6.86 | 4.86 | 3.20 | 1.50 | 10.29 | 8.94 | 0.98 | 0.47 | 0.08 | 0.13 |
| C. drakei | Song et al.44 | 10.27 | 3.96 | 1.05 | 1.96 | 4.65 | 2.92 | 1.79 | 1.54 | 2.00e-04 | 0.06 |
| C. ljungdahlii | Al-Bassam et al.24 | 4.37 | 2.41 | 2.33 | 1.58 | 4.06 | 2.19 | 2.19 | 2.53 | 0.27 | 0.15 |
| 2,3-BDO metabolism | |||||||||||
| A. woodii | Shin et al.45 | 6.96 | 8.63 | 0.10 | 0.23 | 9.84 | 8.83 | 0.35 | 0.34 | 0.048 | 0.35 |
| A. woodii | Song et al.44 | 6.82 | 8.48 | 0.27 | 0.24 | 9.37 | 8.21 | 0.34 | 0.32 | 0.047 | 0.85 |
| E. limosum | Song et al.46 | 5.81 | 5.70 | 3.76 | 3.12 | 8.19 | 7.41 | 1.81 | 1.95 | 0.15 | 0.12 |
| E. limosum | Song et al.44 | 6.44 | 6.12 | 2.09 | 3.12 | 8.18 | 7.42 | 1.80 | 1.95 | 0.066 | 0.12 |
| C. drakei | Song et al.44 | 6.02 | 8.66 | 0.35 | 1.18 | 5.99 | 5.17 | 4.69 | 1.04 | 0.50 | 0.03 |
| C. ljungdahlii | Al-Bassam et al.24 | 6.74 | 7.16 | 1.47 | 1.27 | 6.13 | 6.68 | 2.13 | 1.17 | 1.00 | 0.06 |
| EG metabolism | |||||||||||
| A. woodii | Shin et al.45 | 11.57 | 11.85 | 1.93 | 0.98 | 14.64 | 14.13 | 1.05 | 1.04 | 1.27e-05 | 3.47e-06 |
| A. woodii | Song et al.44 | 11.22 | 11.44 | 2.24 | 0.97 | 13.97 | 13.56 | 1.38 | 1.27 | 1.00e-04 | 2.98e-05 |
| C. drakei | Song et al.44 | 7.17 | 4.60 | 2.11 | 2.22 | 1.91 | 3.30 | 0.25 | 2.51 | 0.07 | 0.10 |
Table showing the mRNA counts and ribosome-protected fragments in autotrophic and heterotrophic condition in each acetogen for pathways where translational efficiency was found differentially regulated. Shown are the median (MDN) value and the median absolute deviation (MAD) for each pathway in each dataset. The table also displays the Wilcoxon's rank-sum test p value carried out to assess the statistical significance of the difference between RNA and RPF in each growth condition for each pathway. Abbreviations: BDO: butanediol; EG: ethylene glycol.